ABSTRACT
Objective To study the clinicopathologic characteristics and the prognostic factors of gastric stump cancer (GSC). Methods A total of forty-seven patients with GSC from Jan 2000 to Dec 2006 were enrolled in this study for retrospective analysis. Initial surgery was performed for gastric benign disease in 39 patients and for malignant disease in 8 patients, which were divided into 2 groups for analysis. The prognosis of all 47 patients were analyzed. Results The mean interval between previous gastrectomy and diagnosis of GSC was 24.4 years. Tumor developed mostly in the patients with Billroth- Ⅱ reconstruction, and male more than female. Tumor located at anastomotic site mostly, at stump stomach and cardia secondly. The mean interval for patients who had undergone their first gastrectomy for malignant disease was shorter than that with benign disease(P＜0.05). Histology, therapy and prognosis showed no significant differences between two groups (P＞0.05). Disease TNM stage and total radical gastrectomy were shown to be significant predictor for the outcome of patients with GSC (P ＜0.01). Conclusion Now the GSC patients with initial surgery performed for malignant disease are increased, which are no siginificant different to patients with benign disease. Early diagnosis and an aggressive surgical approach are crucial to achieve better outcomes for patients with GSC.
ABSTRACT
Recent evidence has increasedly supposed cancer stem cell theory.that cancers can be viewed as an abnormal organ in which tumor growth is driven by a population of cancer stem cells,with self-re-hewing and muti-differentiation potentiality.CD133 has been repofled sequentially in many malignan-cies.Although the biological function of CD133 is not well understood.the CD133 epitope cueeently senves as a useful marker for the isolation of cancer stem cells.Research has discovered that CD133+ tumor cells are in re-lation to tumorigenesis,invasion,metastasis,drug-resistance and recurrence.So,understanding the molecular bi-ology of the CD133+ tumor cells is essential for developing more effective anti-cancer tIeatments,especiallv tar-geting cancer stem cells.